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Journal of Big Data
Fig. 6 | Journal of Big Data

Fig. 6

From: Conventional dendritic cell 2 links the genetic causal association from allergic asthma to COVID-19: a Mendelian randomization and transcriptomic study

Fig. 6

EXOC4, ZBTB46, TLR1, and TNFSF4 variations promote cDC2 differentiation and cDC2 mediates SARS-CoV-2 antigen presentation in AA. A The basic characteristics of instrumental variable SNPs of AA. B Metascape functional enrichment based on corresponding genes of instrumental variable SNPs of AA. C, D The differentiation potential of Pre-DCs in AA/COVID-19 and controls. E Pseudotime trajectories of Pre-DCs, cDC1s, and cDC2s in the UMAP plot. F The differentiation correlation levels of ZBTB46 and EXOC4 in AA and controls. G The expression alterations of ZBTB46 and EXOC4 in cDC2s as related to the increase in Pseudotime. H, I 3D protein docking showing the process of SARS-CoV-2 antigen presentation of cDC2s. J The expression level of TNFSF4 and TLR1 between AA and controls. S spike protein

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