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Journal of Big Data
Fig. 5 | Journal of Big Data

Fig. 5

From: Conventional dendritic cell 2 links the genetic causal association from allergic asthma to COVID-19: a Mendelian randomization and transcriptomic study

Fig. 5

Conventional dendritic 2 cells (cDC2s) are increased/activated in AA exacerbation and downregulated/activated in severe COVID-19. A UMAP plot of total cells from AA and COVID-19, with each cell color coded for cell type. B The proportion of DC in AA/COVID-19 and controls. C UMAP plot of DC populations from AA and COVID-19, with each cell color coded for cell subtype. D Bubble plot showing marker genes for cell subtype annotation. E The proportion of DC subtypes in AA/COVID-19 and controls. F The level of energy metabolism of cDC2 in AA/COVID-19 and controls. G Intercellular communication from cDC2 to other cells. H The number of interactions from cDC2 to T cells in AA/COVID-19 and controls. Bln samples at baseline, Ag samples receiving antigen, AC allergic non-asthmatic controls, HC healthy controls, S patients with severe COVID-19 infection

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