Fig. 4

The HIF-1α score system significantly associated with clinicopathological characteristics in HCC. A–C The HIF-1α score system significantly correlated with advanced TNM stage (A), histologic grade (B) and vascular invasion (C) in HCC. D–F Significant differences of HIF-1α score were found among HCC patients with different TNM stage (D), histologic grade (E), and vascular invasion (F). G Univariate Cox regression analysis showed that the HIF-1α score system, TNM stage, and vascular invasion were prognostic factors for HCC patients’ survival. H Multivariate Cox regression analysis showed that the HIF-1α score system and TNM stage were independent unfavorable prognostic factors for HCC patients’ survival. (I-K) ROC curves analysis for 1-, 3-, and 4-year OS prediction based on the HIF-1α score system, TNM stage, histologic grade, and vascular invasion