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Journal of Big Data
Fig. 6 | Journal of Big Data

Fig. 6

From: Liquid biopsy-based identification of prognostic and immunotherapeutically relevant gene signatures in lower grade glioma

Fig. 6

Immune-related features of RRG-related subtypes. a Heatmap of the relationship between RRG-related subtypes and 28 immune cell subpopulations identified by a previous study. IDH1 status, Gender, vital status, histologic subtype, grade and RRG-related subtypes are shown as patient annotations. b boxplots of the relationship between RRG-related subtypes and 28 immune cell subpopulations. The upper and lower ends of the boxes represented interquartile range of values. The lines in the boxes represented median value, and black dots showed outliers. c Immune activation-relevant genes (CD8A, CXCL10, CXCL9, GZMA, GZMB, IFNG, PRF1, and TBX21) expressed in three RRG-related subtypes. d Immune-checkpoint-relevant genes (CD274, CTLA4, HAVCR2, LAG3, PDCD1, PDCD1LG2, and TIGIT) expressed in three RRG-related subtypes. e EMT-relevant genes (CLDN3, CLDN7, CLDN4, CDH1, VIM, TWIST1, ZEB1, and ZEB2) expressed in three RRG-related subtypes. Within each subtype, the upper and lower ends of the boxes represented interquartile range of values. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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