Prediction of chemoresistance trait of cancer cell lines using machine learning algorithms and systems biology analysis

Journal of Big Data

Table 6 The TFs related to both upregulated and down regulated genes. In the upregulated genes the TFs are down and in the down regulated genes the TFs are up

TFs-ups	TARGET-downs	Relation	TFs-ups	TARGET-downs	Relation	TFS-donws	Targets-Ups	Repression
ATF3	IFNG	Activation	PROX1	IFNG	Repression	AR	CTNNB1	Activation
CREB1	IFNG	Activation	RELA	IFNG	Activation	CTNNB1	PLD1	Activation
CREB1	IFNG	Repression	RELA	IFNG	Unknown	ESR1	CTNNB1	Repression
CREB1	IFNG	Unknown	RFX5	IFNG	Unknown	LEF1	CTNNB1	Unknown
DACH1	TNFSF11	Repression	SIRT2	NEDD4	Repression	NELFCD	CTNNB1	Repression
E2F1	TNFSF11	Activation	SOX10	EDNRB	Unknown	NKX2-5	CTNNB1	Unknown
EGR1	IFNG	Unknown	SP1	BTK	Unknown	PGR	PLD1	Unknown
EOMES	IFNG	Unknown	SP1	EDNRB	Activation	RXRA	PLD1	Unknown
EP300	IFNG	Activation	SP1	EDNRB	Unknown	SIRT1	CTNNB1	Repression
GATA1	IFNG	Unknown	SP3	BTK	Unknown	SOX6	CTNNB1	Repression
GATA3	IFNG	Unknown	SPI1	ACP5	Activation	SP3	TFF2	Repression
HIF1A	EDNRB	Activation	SPI1	BTK	Unknown	TCF4	PLD1	Activation
HSF2	TNFSF11	Activation	STAT1	IFNG	Activation	TCF7L2	CTNNB1	Unknown
IRF1	IFNG	Activation	STAT1	IFNG	Repression	TP53	CTNNB1	Repression
JUN	IFNG	Activation	STAT1	IFNG	Unknown	VDR	PLD1	Unknown
JUN	IFNG	Unknown	STAT3	IFNG	Repression	ZNF24	CTNNB1	Activation
MITF	ACP5	Activation	STAT4	IFNG	Unknown
MSC	IFNG	Activation	STAT5A	IFNG	Activation
MYCN	IFNG	Unknown	STAT5B	IFNG	Unknown
NFATC1	IFNG	Unknown	TBX21	IFNG	Activation
NFATC2	IFNG	Unknown	TBX21	IFNG	Unknown
NFIL3	IFNG	Unknown	TFAP4	IFNG	Unknown
NFKB1	IFNG	Activation	USF1	IFNG	Unknown
NFKB1	IFNG	Unknown	YY1	IFNG	Activation
PARP1	IFNG	Unknown	YY1	IFNG	Repression
			YY1	IFNG	Unknown