Fig. 6

Association between HIF-1α score and oncologic biological processes and hypoxia status in HCC. A Heatmap to exhibit 27 differential crucial oncologic biological pathways overlapped among the three HIF-1α score groups. B–D Stepwise increasing Buffa (B), Ragnum (C), and Winter (D) hypoxia scores were found from low to high HIF-1α score group. (E–G) HIF-1α score significantly associated with Buffa (E), Ragnum (F), and Winter (G) hypoxia score systems. H–K KM survival 6curves for OS of HCC patients according to the HIF-1α (H), Buffa (I), Ragnum (J), and Winter (K) score systems in the TCGA cohort. L–N ROC curves for 1- (L), 3- (M), and 4- (N) year OS prediction based on the HIF-1α, Buffa, Ragnum, and Winter score systems in the TCGA cohort