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Table 7 The annotations of transcription factors regulating the harvested genes from the feature selection step

From: Prediction of chemoresistance trait of cancer cell lines using machine learning algorithms and systems biology analysis

Term P-value Adjusted P-value Genes
Pathways in cancer 1.2063332677701377E−19 3.715506464732024E−17 STAT5A;STAT5B;TCF7L2;JUN;SPI1;STAT1;LEF1;STAT3;MITF;HIF1A;ESR1;RELA;NFKB1;AR;RXRA;SP1;E2F1;STAT4;EP300;CTNNB1;TP53
Wnt signaling pathway 9.705297353623653E−9 1.5732797815347815E−7 TCF7L2;JUN;LEF1;EP300;NFATC2;CTNNB1;NFATC1;TP53
Non-small cell lung cancer 2.334429995619187E−8 3.126106255003085E−7 STAT5A;STAT5B;RXRA;STAT3;E2F1;TP53
TNF signaling pathway 5.026455978790371E−7 4.553377769021866E−6 ATF2;JUN;CREB1;IRF1;RELA;NFKB1
JAK-STAT signaling pathway 4.820060593301115E−6 3.620923567650594E−5 STAT5A;STAT5B;STAT1;STAT3;STAT4;EP300
Small cell lung cancer 5.15158695877854E−6 3.6899739146599775E−5 RXRA;E2F1;TP53;RELA;NFKB1
HIF-1 signaling pathway 7.356942182113052E−6 5.035418204646267E−5 STAT3;EP300;HIF1A;RELA;NFKB1
cAMP signaling pathway 2.2332816777813463E−5 1.4037770546054178E−4 JUN;CREB1;EP300;NFATC1;RELA;NFKB1
Apoptosis 4.156130787036355E−5 2.3274332407403588E−4 JUN;PARP1;TP53;RELA;NFKB1
Adherens junction 4.260972052484695E−5 2.3435346288665825E−4 TCF7L2;LEF1;EP300;CTNNB1
MAPK signaling pathway 1.39454465445684E−4 7.158662559545113E−4 ATF2;JUN;NFATC1;TP53;RELA;NFKB1
Toll-like receptor signaling pathway 1.786661621004991E−4 8.59830905108652E−4 JUN;STAT1;RELA;NFKB1
PI3K-Akt signaling pathway 3.7197722896986754E−4 0.0016604200945321624 ATF2;CREB1;RXRA;TP53;RELA;NFKB1
cGMP-PKG signaling pathway 0.0010478054962433662 0.0042463696426704835 ATF2;CREB1;NFATC2;NFATC1
ErbB signaling pathway 0.0015715511019872403 0.006205612043744487 STAT5A;STAT5B;JUN
NF-kappa B signaling pathway 0.002160916108972604 0.008116611726384903 PARP1;RELA;NFKB1
Sphingolipid signaling pathway 0.004084635694037895 0.014800797573690256 TP53;RELA;NFKB1
Cell cycle 0.004582612813265843 0.01641214821495209 E2F1;EP300;TP53
FoxO signaling pathway 0.005453058494504465 0.01930508064721121 STAT3;EP300;SIRT1
Hippo signaling pathway 0.009248140092633821 0.03130139723660678 TCF7L2;LEF1;CTNNB1