Table 1 Comparison of BEST with other tools
From: BEST: a web application for comprehensive biomarker exploration on large-scale data in solid tumors
Tools | BEST | GEPIA | Xena | ExpressionAtlas | HPA | UALCAN | PrognoScan | PROGgeneV2 |
|---|---|---|---|---|---|---|---|---|
Pancancer | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
Multiple datasets | ✓ | ✗ | ✓ | ✓ | ✗ | ✗ | ✓ | ✓ |
Analytic target | ||||||||
Single gene | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
Gene list | ✓ | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✓ |
Clinical association | ||||||||
Tidy data | ✓ | ✗ | ✗ | ✗ | ✗ | ✓ | ✗ | ✗ |
General characteristics | ✓ | ✗ | ✓ | ✓ | ✓ | ✓ | ✗ | ✗ |
Histological characteristics | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✗ | ✗ |
Molecular characteristics | ✓ | ✗ | ✓ | ✗ | ✗ | ✓ | ✗ | ✗ |
Treatment responses | ✓ | ✗ | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ |
Survival analysis | ||||||||
Multiple outcomes | ✓ | ✓ | ✓ | ✗ | ✗ | ✗ | ✓ | ✓ |
Multiple cutoff options | ✓ | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✓ |
Cox regression analysis | ✓ | ✓ | ✗ | ✗ | ✗ | ✗ | ✓ | ✓ |
Kaplan-Meier analysis | ✓ | ✓ | ✓ | ✗ | ✓ | ✓ | ✓ | ✓ |
Enrichment analysis | ||||||||
ORA | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
GSEA | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
Cell infiltration | ||||||||
CIBERSORT | ✓ | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
CIBERSORT_ABS | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
EPIC | ✓ | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
ESTIMATE | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
MCP-counter | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
Quantiseq | ✓ | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
TIMER | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
xCell | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
Immunomodulator | ||||||||
Antigen presentation | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
Immunoinhibitor | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
Immunostimulator | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
Chemokine | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
Receptor | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
Immunotherapy | ||||||||
DEA | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
ROC analysis | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
Survival analysis | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
Drug analysis | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
Genomic analysis | ✓ | ✗ | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ |