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Journal of Big Data
Fig. 2 | Journal of Big Data

Fig. 2

From: Identification of tumor antigens and anoikis-based molecular subtypes in the hepatocellular carcinoma immune microenvironment: implications for mRNA vaccine development and precision treatment

Fig. 2

Recognition potential mRNA antigen associated tumor antigens and scenery of genetic and expression profiles of anoikis related regulators in hepatocellular carcinoma. A Chromosomal distribution of potential genes encoding liver cancer antigens. B HCC patients’ s samples overlapping in the altered genome fraction group C HCC patients’ s samples overlapping in the mutation count group. D Summary of Potentially Mutated Genes in Liver Cancer. E Venn diagram of liver cancer antigen gene identification, 8 antigen genes are highly expressed, mutated, and related to OS and RFS. F The HCC most frequently mutated genes in the altered genome fraction group. G The HCC most frequently mutated genes mutation count group. H, I The OncoPrint tab of genomic alterations in the TCGA dataset. J The frequency of the top 20 highly mutated anoikis related genes in HCC. K Heat map of the relationship between the tumor microenvironment and the identified potential antigen genes for liver cancer in the TCG database. *p < 0.05; **p < 0.01; ***p < 0.001

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