Table 1 Characteristics of the study populations
20 medical centers | BTH | BFH | CZMC | SYMC | SZMC | WJMC | ||||
|---|---|---|---|---|---|---|---|---|---|---|
Development dataset | Internal validation dataset | External validation dataset 1 | External validation dataset 2 | External validation dataset 3 | External validation dataset 4 | External validation dataset 5 | External validation dataset 6 | |||
Model 1 | Model 2 | Model 1 | Model 2 | |||||||
Participants | 5080 | 5080 | 717 | 717 | 227 | 191 | 363 | 363 | 363 | 363 |
Hyperthyroidism | 1804 | 1804 | 251 | 251 | 105 | 101 | 116 | 128 | 133 | 129 |
Non-hyperthyroidism | 3276 | 3276 | 466 | 466 | 122 | 90 | 247 | 235 | 230 | 234 |
Age, years | 46 (20–88) | 40 (15–85) | 45 (19–88) | 41 (16–88) | 50 (40–60) | 43 (34–56) | 47 (24–88) | 46 (20–73) | 47 (24–88) | 46 (24–82) |
Gender | ||||||||||
Male | 2072 | 1938 | 344 | 327 | 114 | 73 | 188 | 166 | 168 | 150 |
Female | 3008 | 3142 | 373 | 390 | 113 | 118 | 178 | 197 | 195 | 213 |
Body Mass Index, kg/m2 | 22.8 (17.0–28.2) | 23.6 (17.2–28.9) | 23.3 (16.8–28.9) | 23.6 (16.9–28.1) | 23.2 (16.8–27.2) | 22.5 (16.2–28.0) | 23.3 (16.4–28.7) | 23.3 (17.2–28.5) | 23.9 (15.9–27.8) | 23.2 (16.5–28.3) |
Systolic blood pressure, mm Hg | 130 (88–175) | 128 (86–173) | 129 (88–173) | 128 (83–175) | 126 (86–173) | 124 (83–175) | 130 (87.4–171) | 129 (88–179) | 130 (86–173) | 130 (88–175) |
Diastolic blood pressure, mm Hg | 78 (49–107) | 78 (47–106) | 77 (47–105) | 78 (49–106) | 80 (48–105) | 75 (47–106) | 78 (50–102) | 77 (49–106) | 78 (48–106) | 79 (48–105) |
Retinal photographs | 10,160 | 10,160 | 1434 | 1434 | 592 | 366 | 726 | 726 | 726 | 726 |
Hyperthyroidism | 3608 | 3608 | 502 | 502 | 296 | 183 | 232 | 256 | 266 | 258 |
Non-hyperthyroidism | 6552 | 6552 | 932 | 932 | 296 | 183 | 494 | 470 | 460 | 468 |